By Susan L. McElroy, Paul E. Keck Jr., Robert M. Post
Numerous antiepileptic medicinal drugs (AEDs) now have regulatory symptoms for treating bipolar ailment. there's growing to be facts that AEDs ordinarily have various important psychotropic results. This e-book is the 1st accomplished, clinically orientated, reference at the use of AEDs to regard a number of psychiatric issues reminiscent of temper, psychotic, nervousness, substance use, consuming, and character problems. Written through the best medical specialists, Antiepileptic medicines to regard Psychiatric problems: is equipped by means of psychiatric affliction for less complicated details accumulating, and allows the medical professional to take advantage of the textual content as a stand by myself reference is the 1st finished reference booklet clinically oriented to using AEDs to regard psychiatric disorders—other books have fascinated with drug mechanisms and drug interactions
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Additional resources for Antiepileptic Drugs to Treat Psychiatric Disorders (Medical Psychiatry Series)
Medical therapy of epilepsy: when to initiate treatment and when to combine? J Neurol 2005; 252(2):125–130. 51. Beghi E, Gatti G, Tonini C, et al. BASE study group. Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial. Epilepsy Res 2003; 57(1):1–13. 3d] [29/4/08/11:27:19] [17–32] Antiepileptics in the Treatment of Epilepsy 31 52. Perucca E, Dulac O, Shorvon S, et al. Harnessing the clinical potential of antiepileptic drug therapy: dosage optimisation.
Older-generation AEDs have been associated with a two- to threefold increased risk for major congenital malformations in the offspring exposed to these agents in utero (17,18). Such risks, however, have to be balanced against the fetal and maternal risks associated with uncontrolled epileptic seizures during pregnancy (17). The strategy has been to use the appropriate AED for the patient’s type of epilepsy in monotherapy at the lowest effective dosage to maintain seizure control throughout pregnancy.
Of note, the ILAE guidelines are probably the strictest and most demanding with respect to assessment of the available evidence and, as a result, leave the practitioner with little guidance in many instances. The National Institute of Clinical Excellence (NICE) in the United Kingdom has also issued evidence-based guidelines, specifically assessing the role of the newer-generation AEDs (13). They conclude that evidence does not suggest differences in effectiveness in seizure control between newer and older AEDs in monotherapy.