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By Bruce C Baguley; David J Kerr

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This area of the receptor contains key tyrosine residues which, when phosphorylated, represent a variety of consensus binding sites for SH2 domains that are present in various proteins involved in signal transmission (Pawson and Schlessinger, 1993; Schlessinger and Ullrich, 1992). , 1996). , 1997). Since the C-terminal tail represents an area where the least sequence homology exists between the four receptors, this represents a mechanism whereby different sets of signaling proteins can be recruited, depending on which receptors are activated and what binding sites are phosphorylated.

W. K. A. , and Roth, J. A. (1995). Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res. 55, 3250–3253. , and Pommier, Y. (1999). Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the eight human breast cancer cell lines of the NCI anticancer drug screen: multifactorial relationship with topoisomerase I, protein kinase C, bcl-2 and caspase pathways. Int. J. Cancer 82, 396–404. , and Hoffmann, I. (2000).

Biol. Chem. 275, 10342–10348. t P~ I (-rC~x) 1_~ ! [~ ;~ . . . . . . . . . . . . . . . . . . . . . . . . . I l l [ CHAPTER 2, FIGURE 2 Molecular interaction map of the E2F-dependent control of the GI-S cell cycle phase transition. The symbols used are as defined by Kohn (1999). html). (1) The transition from G1 to S phase requires E2F-dependent gene products and an as-yet-undefined action of cyclin E. (2) E2F-dependent genes include regulators such as cyclin E and c-Myc, in addition to many genes that manufacture the S-phase machinery (not shown).

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