By Amy Borenstein, James Mortimer
Alzheimer's affliction: Lifecourse views on possibility aid summarizes the starting to be physique of information at the distribution and explanations of Alzheimer’s illness (AD) in human populations, delivering the reader with wisdom on how we outline the illness and what its probability and protecting components are within the context of a life-course method.
At the realization of the ebook, the reader will comprehend why Alzheimer’s illness most likely starts at notion, then progresses via early-life and grownup danger components that eventually effect the stability among pathologic insults within the mind and the facility of the mind to switch ailment indicators. unlike edited volumes that can have little team spirit, this e-book makes a speciality of an built-in life-course method of the epidemiology of dementia, particularly, Alzheimer’s illness.
- Reviews the present technological know-how surrounding Alzheimer’s disease
- Provides a primer of foundational wisdom at the disease's epidemiology and biostatistics
- Utilizes a life-course method, offering a singular and built-in view of the evolution of this affliction from genes to mind reserve
- Uses the ‘threshold model’—a conception first defined by means of Dr. Mortimer and extensively authorised today—which contains the belief of threat elements for the pathology and expression of the illness
- Proposes that bettering mind well-being via modifiable behaviors can hold up affliction onset till a later age
- Examines the way forward for prevention of Alzheimer’s sickness, a topic of significant present interest
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Extra resources for Alzheimer's disease : life course perspectives on risk reduction
There is a vast literature on what is commonly termed “non-AD dementias” that is beyond the scope of this book. In addition, an individual can have more than one subtype of dementia. In fact it is common for multiple pathologies to be present together. , 2005). 14 SECTION | I Defining a Case A representative autopsy study in Chicago (Schneider, Arvanitakis, Bang, & Bennett, 2007) demonstrated that, of 80 cases fulfilling neuropathologic criteria for AD, 46% had AD with no other pathology and 39 (49%) had two pathologies (25 AD with vascular infarcts, 12 with AD and Parkinson’s disease or Lewy body disease, and 2 with AD and another pathology, such as a brain tumor or amyloid angiopathy with multiple hemorrhages).
While these data can give us valuable prevalence figures that represent all people in the United States aged 70 and over, the small numbers and potentially biased follow-up preclude valid estimates of incidence rates by region of the United States or by race or ethnicity. A large, national cohort study of AD and other dementias is sorely needed that would examine risk factors for incidence within multiple racial/ethnic and cultural groups with a standardized methodological framework. As we shall discuss in Chapters 6 and 7, most current data come from studies conducted in one geographic region on one population subgroup, with a few of these individual studies enrolling multiple racial or ethnic groups.
2011). For “MCI due to AD,” some experts have proposed the use of the term, “prodromal AD” to get at the concept of the continuum, rather than discrete categories of clinical diagnoses. , 2001, 1999). This small change in the operationalization of this criterion for MCI could increase misclassification between the diagnoses of MCI and dementia, which would increase the prevalence and incidence rates for MCI and reduce those for dementia (Morris, 2012). In a study examining this misclassification, Morris (2012) argues that the diagnosis of MCI might best be restricted to non-AD dementias, while those who have “MCI due to AD” be called “preclinical,” “prodromal,” or “early” AD.