By Stefan Guhlke (auth.), Jan Bucerius, Hojjat Ahmadzadehfar, Hans-Jürgen Biersack (eds.)
99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that's usual for the imaging of myocardial perfusion, in addition to quite a few malignant and benign illnesses. 99mTc-Sestamibi – scientific purposes offers an in depth and informative evaluate of virtually all of the oncologic and non-oncologic functions of 99mTc-sestamibi SPECT, together with a number of particularly infrequent symptoms. assorted disease-related protocols for 99mTc-sestamibi SPECT are offered, and for every ailment a finished precis of the suitable pathology and epidemiology is supplied. all through, there's a powerful emphasis at the useful elements of use of this renowned tracer, together with directions for the guidance of a number of commercially on hand tracer kits. scientific practitioners will locate this publication to be a useful advisor to the appliance and advantages of 99mTc-sestamibi SPECT in either the inpatient and the outpatient setting.
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Radiochemical purity of Sestamibi may also play an important role in parathyroid imaging: Karam et al.  used a procedure to decrease the Technetium to Sestamibi ratio thus improving the radiochemical purity of 99mTc-Sestamibi. They achieved a higher degree of radiochemical purity (at least 95% bound), which increased the sensitivity from 94% to 84% in patients with disease parathyroid glands. 5 Sestamibi and Histology in Parathyroid Adenoma Gupta et al.  published data on 35 patients with preoperative Sestamibi localization to optimize a surgical approach.
Do not heat! 0 cm from the spot. 0 cm from the bottom, and measure each piece in your dose calibrator. (f) Calculate the% Radiochemical purity as: 30 H. Ahmadzadehfar and A. Sabet % Tc-99m-sestamibi = (Activity top portion)/(Activity both pieces) × 100. % Tc-99m-sestamibi should be >94%; otherwise the preparation should be discarded. Note: Do not use material if the radiochemical purity is less than 94%. Tc-99m-sestamibi is to be used within 10 h of reconstitution and the container and any unused contents should be disposed in accordance with local requirements for radioactive materials.
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